{"id":1733,"date":"2022-11-02T10:01:17","date_gmt":"2022-11-02T10:01:17","guid":{"rendered":"https:\/\/cognotekt.com\/?p=1733"},"modified":"2023-03-15T09:51:37","modified_gmt":"2023-03-15T09:51:37","slug":"biopharmaceutical-models-that-work-1-somatic-gene-therapy","status":"publish","type":"post","link":"https:\/\/cognotekt.com\/en\/biopharmaceutical-models-that-work-1-somatic-gene-therapy","title":{"rendered":"Biopharmaceutical models that work (1): Somatic gene therapy"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"1733\" class=\"elementor elementor-1733\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-7c4c5cd elementor-section-height-min-height elementor-section-content-middle elementor-section-boxed elementor-section-height-default elementor-section-items-middle\" data-id=\"7c4c5cd\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;sticky&quot;:&quot;top&quot;,&quot;sticky_on&quot;:[&quot;desktop&quot;,&quot;tablet&quot;,&quot;mobile&quot;],&quot;sticky_offset&quot;:0,&quot;sticky_effects_offset&quot;:0,&quot;sticky_anchor_link_offset&quot;:0}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-7df4f38\" data-id=\"7df4f38\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-4f32e69 elementor-widget elementor-widget-image\" data-id=\"4f32e69\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/cognotekt.com\/\">\n\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"800\" height=\"300\" src=\"https:\/\/cognotekt.com\/wp-content\/uploads\/2022\/08\/Cognotekt_RGB_Original@2x-1024x384.png\" class=\"attachment-large size-large wp-image-85\" alt=\"Cognotekt_RGB_Original\" srcset=\"https:\/\/cognotekt.com\/wp-content\/uploads\/2022\/08\/Cognotekt_RGB_Original@2x-1024x384.png 1024w, https:\/\/cognotekt.com\/wp-content\/uploads\/2022\/08\/Cognotekt_RGB_Original@2x-300x113.png 300w, https:\/\/cognotekt.com\/wp-content\/uploads\/2022\/08\/Cognotekt_RGB_Original@2x-768x288.png 768w, https:\/\/cognotekt.com\/wp-content\/uploads\/2022\/08\/Cognotekt_RGB_Original@2x-1536x576.png 1536w, https:\/\/cognotekt.com\/wp-content\/uploads\/2022\/08\/Cognotekt_RGB_Original@2x.png 2000w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-62500aa\" data-id=\"62500aa\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-904f117 elementor-nav-menu__align-center elementor-nav-menu--stretch elementor-nav-menu--dropdown-tablet elementor-nav-menu__text-align-aside elementor-nav-menu--toggle elementor-nav-menu--burger elementor-widget elementor-widget-nav-menu\" data-id=\"904f117\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;full_width&quot;:&quot;stretch&quot;,&quot;layout&quot;:&quot;horizontal&quot;,&quot;submenu_icon&quot;:{&quot;value&quot;:&quot;&lt;i class=\\&quot;fas fa-caret-down\\&quot; 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But which type of gene therapy?<\/p><p>Exhaustive experiments with CRISPR\/Cas in the mammalian germ line have shown that the technology cannot be safely used in eukaryotic germ cells, because this recombination system has too many serious genetic side effects. These comprise unintended single nucleotide edits, but more importantly, massive chromosome damage such as chromothripsis and loss of heterozygosity in 30 to 40 percent of all CRISPR-Cas9-targeted human embryonic cells. The usage of CRISPR-Cas9 in the human germ line would with high likelihood result in genetically damaged human chimeras.<\/p><p>But what about somatic gene therapy using CRISPR\/Cas? There are two areas in which it can be envisaged: (i) extra-corporal gene targeting in vitro in circulating cells or their precursors and (ii) in organs with good accessibility and natural local limitation of the intervention\u2019s scope.<\/p><p><strong>Promise and challenges<\/strong><br \/>Extra-corporal gene targeting, which can be used, for example, in hemoglobinopathies such as sickle cell disease and beta-thalassemia, has the advantage that the delivery of the CRISPR\/Cas machinery together with the required nucleic acids (gRNA, repair template) to the target cell is much simpler in vitro by using simple electroporation than in vivo with vectors. The target cells can be isolated, genetically manipulated and can \u2013 albeit without full certainty \u2013 be screened for unintended edits or chromosome damage before reinfusion into the circulation. This also enables an exact dosage of the therapeutic principle.<\/p><p>For somatic cells in solid organs, the procedure is much more complicated because vectors must be used. Multiple problems can arise.<\/p><p>First, delivery: Lipid nanoparticles can get caught in the liver and fail to distribute to the target organ properly. The question of the toxicity of different lipid coats itself is not yet fully clarified. Viral vectors may elicit immune reactions with the potential to reduce or thwart efficacy. They are furthermore limited with regard to the size of the cargo they can carry. There is no possibility to achieve an exact dosage.<\/p><p>Second, specificity: It may be hard to limit expression of the CRISP-system to the right cells in the target organ despite the usage or specific promoters.<\/p><p>Third, safety: The system may introduce undesired point mutations and chromosomal aberrations into somatic cells, which may cause cancer or other systemic diseases such as auto-immune conditions. This concern applies to both somatic gene therapy approaches, but is more severe in organ therapy because the genetic side effects cannot be assessed before the therapy, but occur under it.<\/p><p>Currently, the most promising somatic organ gene therapy target is the eye because as a part of the brain, the retina is situated behind the blood-brain barrier and the retina is anatomically separated from other organs by the orbita. Multiple clinical trials are ongoing.<\/p><p><strong>Conclusions<\/strong><br \/>Somatic gene therapy with CRISPR\/Cas and other methods of gene targeting is still in its infancy \u2013 as it has been since the 1990s. Since then, many challenges have been overcome, but more progress is needed. Currently, the most promising approaches are extra-corporal targeting methods because modified cells can be screened to some extent for undesired effects of the genetic manipulation, which is impossible when targeting organs.<\/p><p>Contact us to tell us about your challenges in biopharmaceutical R&amp;D or marketing to see if we can help you.<\/p><p>Register here for our Cognotekt Biopharma Series brought to you every week by Cognotekt.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-2a5904b elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"2a5904b\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column 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But which type of gene therapy? Exhaustive experiments with CRISPR\/Cas in the mammalian germ line have [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"elementor_canvas","format":"standard","meta":{"footnotes":""},"categories":[28],"tags":[],"class_list":["post-1733","post","type-post","status-publish","format-standard","hentry","category-thought-leadership_en"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.1.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Biopharmaceutical models that work (1): Somatic gene therapy | Cognotekt<\/title>\n<meta name=\"description\" content=\"Since CRISPR\/Cas was discovered ten years ago and made available for usage in eukaryotic cells, this genetic recombination technology has raised high hopes and revived the prospects for gene therapy.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, 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